Home » NFL Picks » COLTS @ 49ERS


Having been selected to be this week's Sunday Night Football, we should see a great game against two potential playoff candidates. First, read this article and find out what you should be careful about before you put money on the line, and later in the article, you will find this week's pick of the game.


  • Matchup: NFC & AFC
  • Expert Picks: Legal Sports Betting
  • Venue: Levi's Stadium
  • Location: Santa Clara, CA
  • Date: October 24, 2021
  • Time: 8:20 pm
  • TV: NBC
  • Bet: BetMGM | 888 | Borgata


  • Money-Line: San Francisco 49ers -200, Indianapolis Colts +175
  • Total: Over/Under 44.5

Here is what to know about Colts

The Indianapolis Colts head into this game 2-4 for this season. In their last contest, the Colts faced off with the Texans and took home the win by a score of 31-3. Carson Wentz went 11/20 with 223 yds passing and 2 touchdowns. He had a QB rate of 127.7 and ended the contest without throwing a pick. T.Y. Hilton left with an average of 20.0 yds per catch by earning 80 yards on 4 catches. Jonathan Taylor was the rushing leader for the Colts with 14 attempts for 145 yds (10.4 yards per carry). At the end of the game, they had 48 plays which converted into 388 yds. The Indianapolis Colts ended up running the ball 26 times and had 174 yds, which earned them an average of 6.7 yds per carry. Against the rush, the Colts conceded 124 yards on 29 attempts, which calculates to 4.3 yards per rush surrendered. Indianapolis allowed 29 pass completions on 43 tries for a total of 229 yds, and a completion rate of 67.4%.

The Colts currently have 2,205 total yards for the year. Indianapolis has a total of 68 first downs as a unit, and they have committed 24 infractions for 248 yards. With reference to the distribution of touchdowns, Indianapolis has amassed 9 passing touchdowns and 5 rushing touchdowns. They have turned the football over 5 different times (2 picks and 3 fumbles). As a team, they’re maintaining an average of 124.2 yards via the ground game which ranks them 11th in the league. In terms of scoring, the Indianapolis Colts have an average of 23.2 points per outing.

When talking about passing yards, the Colts have conceded 1,533 yards which have them sitting in 21st in football. They have conceded 255.5 yards per outing through the air in addition to giving up a completion percentage of 71.9%. During this campaign, they have given up 366.5 yards per contest which rank them 20th in the league. They have given up 15 touchdowns through the air in addition to 1 touchdown on the ground. They are allowing teams to run for an average of 4.1 yards per running attempt and 111.0 yards on the ground per game for the year. In total, they have conceded 666 rushing yards through 6 games. The Colts are ranked 11th in the NFL when it comes to team defense, conceding 21.8 PPG.

Here is what to know about 49ers

The 49ers come into this game with a record of 2-3 for this year. The last time they took the gridiron, the 49ers took a loss by a final score of 17-10 when they played the Cardinals. Trey Lance walked away from the contest with 192 yards on 15/29 passing while his quarterback rate was 58.4. He threw 1 interception and his average yards per pass attempt was 6.62 yds. Elijah Mitchell carried the ball 9 times for 43 yards, ending the contest with 4.8 yds per carry for San Francisco. Deebo Samuel was featured in the passing game for the 49ers, catching 3 throws for 58 yards (19.3 yds per catch). San Francisco rushed the football for 5.4 yards per tote, finishing the contest with 152 yards on 28 attempts. The 49ers finished the contest with a total of 338 yds on 59 plays (5.7 yds per play). The 49ers secondary conceded a completion percentage of 71.0%, surrendering 210 yds on 22 for 31 passing. San Francisco conceded 27 run attempts for 94 yds (3.5 yds per carry).

When looking at how much they score, the 49ers are sitting 17th in the league scoring 23.4 PPG. For the year thus far, the 49ers have thrown for a total of 1,231 passing yards not to mention holding an average of 246.2 throwing yards per contest, which is ranked 14th in the NFL. They maintain an average of 122.0 yards per game via the ground game and have toted the ball for 610 yards overall. The San Francisco 49ers average 368.2 yards per contest which has them ranked 14th out of all teams in the league. The San Francisco offense has totaled 363 penalty yds on 31 violations, ranking them 27th in the league in terms of making mistakes. They have given away 3 interceptions while losing 4 fumbles and they have been able to obtain 60 first downs.

San Francisco has given up a total of 566 yards on the ground (113.2 yards per outing) in addition to 6 touchdowns by ground for the season. They have yielded 8 touchdowns via the pass as well as 216.6 yards per game, which has them in 7th in the league. Their defense has 2 takeaways (1 fumble recovery and 1 interception) over the course of the season. Over the course of the season, they have conceded 119 points in total. The 49ers defense has been on the field for 312 plays, which ranks them 2nd in football. The 49ers are surrendering 23.8 PPG, which has them sitting 15th in football.

Pick of the Game

49ers have a strong run defense and thanks to that 49ers should be able to limit Jonathan Taylor to under 70 yards. Without Taylor who can take over a game by himself, the Colts should have a tough job at hand. Wentz is improving but the 49ers defense is strong. Take the better defense to win this game and cover the spread -3.5.








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